The study was conducted from November 2010 to March 2011 in Bahir Dar and its surrounding areas, north-western Ethiopia, to determine the prevalence of Bovine schistosomosis and its associated risk factors. A cross sectional study was conducted on coproscopical, abattoir examination to bovine schistosomosis and retrospective study three years health institution record to assess human schistosomiasis. A total of 400 cattle were examined, 300 cattle for field survey and 100 cattle for abattoir survey. From the 300 cattle, 24.3 %( n=73) were found for schistosoma bovis on coproscopic examination. The prevalence of schistosomosis with regarded to body conditions was found 10.3% (poor), 12.3% (medium) and 1.7% (good) and has also statistically signifi cant difference (p= 0.00). The prevalence of the disease was higher in local breed cattle (24.9%) than cross breed cattle (Local x Holstein-Friesian) (18.52%). The prevalence of the disease in was higher in extensive management system (25.18%) than semi-intensive management system (15.38%). However it has no statistically significant difference (P=0.201) between the two management systems. In the second part of the study, 100 cattle slaughtered at Bahir Dar municipal abattoir were examined. Out of these 22 % (n=22) harbored Schistosoma bovis in their mesenteric and portal veins and 10 % (n=10) in coproscopic examination of slaughtered animals. In the third study the infection rate of S. mansoni in human the rate decreases in three consecutive years (2000, 2001, and 2002; 45.1%, 37.0% and 9.8%) respectively. The rate of schistosomiasis was highest in young people (69.0%), adult (15.3%) and old people (7.5%).